Clonality detection through molecular PCR analysis of the rearrangement of immunoglobulin (Ig) and T-cell receptor (TCR) genes is a valuable tool in the diagnosis of B- and T-cell lymphoproliferative processes.
Vitro provides a variety of multiplex PCR kits to detect the presence of clonality by amplifying VDJ and VJ rearranged gene segments of the hypervariable regions of the IgH, IgK-IgL and TCR gamma genes, using a range of primers from the most highly conserved regions of these genes.
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